Wolves vs Reading Live Stream: The hosts were frustrated for much of the first half, until full-back Matt Doherty capitalised on hesitant defending to nod Wolves in front.
Cool second-half finishes from Benik Afobe and Doherty sealed three points.
The win was soured slightly by Wanderers’ top scorer Diogo Jota limping off before the break.
But Villa’s home defeat by QPR on Tuesday means Wolves now have a 10-point buffer to their third-placed rivals with nine matches remaining.
Nuno Espirito Santo’s side had won just one of their past five league games heading into the re-arranged fixture against the Royals, postponed because of snow 10 days ago.
Relive Tuesday’s EFL action
Wolves’ 4-1 loss at Villa Park at the weekend saw the Portuguese make four changes to his side, including a first start for Afobe since returning on loan from Bournemouth in January.
And the DR Congo striker rewarded his manager’s faith, slotting in Helder Costa’s cross, in between Doherty’s double.
The right-back’s two strikes were clinical – the first a neat header from Barry Douglas’ knock back, before stroking the ball in from the edge of the area.
Wolves still have home games to come against four sides in the bottom half – Burton, Hull, Birmingham and Sheffield Wednesday – as they seek a return to the Premier League for the first time since being relegated in 2012.
Reading, who failed to register a shot on target and have only won one of their past 17 matches, remain in relegation trouble in 19th. Wolves manager Nuno Espirito Santo:
“Of course we are happy, but on Saturday we were not happy so we are looking for consistency.
“Today I think it was a deserved win and a well-played game. It was a good game, a good performance and a good result.
“I think our fans enjoyed the game, I think we were in control. We managed every situation well, we defended well and we didn’t give anything to Reading who are a good team.
“We know Diogo [Jota] and when he cannot go on the pitch we know he is in pain. Let’s see how he is.”
Reading boss Jaap Stam:
“Of course I am fed up with losing. I can’t do anything about that [my position] and if they want to make changes you need to go to the owners. I spoke to them [the owners] this morning.
“At the end of the day they are very supportive with what they are doing. In the situation we are in I hate it as well. I want to go forward, I want to win my games.
“Hopefully we can see an end to this run. We need to do things differently and the intensity has to be a lot more.
“If you do things with a certain mindset you can make it more difficult for the opposition.”